Wooden decorative bottle opener sign. Handmade and painted with Mile 0. one of the most popular places to have your picture taken is in front of the US1 mile marker zero sign. Every day, hundreds, if not thousands of visitors, smile for the camera and commemorate visiting the southernmost point of the United States. Stretching from upper Maine to Key West, US 1, known locally as the Overseas Highway, is a 2,369 interstate that connects most major cities in the eastern U.S.